A recent research carried out at the University of Extremadura, by the PARK group[i] , has shown that a fatty acid exclusive to royal jelly induces cellular autophagy (breakdown of substances in the cell’s cytoplasm that are recycled for important cellular functions ) in disease Parkinson ‘s disease and improves neuronal health in various animal models. These studies have shown that royal jelly prolongs the life of the fruit fly.
As we know, royal jelly is a substance produced by worker bees to feed their queen, well known for its use in many food supplements manufactured in ROBIS, especially in drinkable ampoules.
It is known that royal jelly has anti-tumor and anti-inflammatory properties, which have led these researchers from the University of Extremadura to delve into their study, specifically, in its peculiar fatty acids with the aim of observing and analyzing its effects in a mechanism physiological essential such as cellular autophagy .
Cellular autophagy allows the cell to partially “self-digest” in the event of a nutritional deficit and to produce energy, and what is even more important, it removes from the interior of the cell all those altered cellular contents (proteins, mitochondria…) that are damaged. Cellular autophagy, has confirmed this research group, exerts a protective role in neurodegenerative pathologies such as Parkinson’s disease, unfortunately so present in our time.
The results of this first study published in the journal Cell Biology and Toxicology[ii] they are very satisfying. Since they not only induce cellular autophagy, but scientists have observed the neuroprotective effect against neurodegenerative diseases both in animal models and in in vitro cell tests, José Manuel Fuentes, coordinator of the project, has clarified.
Researchers have also found another very interesting effect of this royal jelly fatty acid called QBA: this fatty acid promotes longevity in fruit flies ( Drosophila melanogaster ).
We can conclude with this study, that the induction of autophagy plays a very important role in the beneficial effects for health.
The aim now is to continue this research by introducing these molecules of the fatty acid “QBA” in drinks and animal feed, instead of injecting them, and see if the effect is just as conclusive.
There is great interest in seeking effective autophagy enhancers with nutraceutical properties to improve age-related diseases, such as neurodegenerative disorders, and consequently promote longevity.
Martínez-Chacón G, Paredes-Barquero M, Yakhine-Diop SMS, Uribe-Carretero E, Bargiela A, Sabater-Arcis M, Morales-García J, Alarcón-Gil J, Alegre-Cortés E, Canales-Cortés S, Rodríguez- Arribas M, Camello PJ, Pedro JMB, Perez-Castillo A, Artero R, Gonzalez-Polo RA, Fuentes JM, Niso-Santano M. “Neuroprotective properties of queen bee acid by autophagy induction”. Cell Biol Toxicol. 2021 Aug 27. doi: 10.1007 / s10565-021-09625-w. Epub ahead of print. PMID: 34448959 .